Human GM2A (GM2 Ganglioside Activator) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015599)
SPECIFICATIONS
General Information
| Short Description | This GM2A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.061ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | GM2A |
| Gene ID | 2760 |
| Uniprot ID | SAP3_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. |
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
| Protein Name | Ganglioside Gm2 ActivatorCerebroside Sulfate Activator ProteinGm2-ApSphingolipid Activator Protein 3Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Lysosome |
| Alternative ELISA Names | Ganglioside Gm2 Activator ELISA kitCerebroside Sulfate Activator Protein ELISA kitGm2-Ap ELISA kitSphingolipid Activator Protein 3 ELISA kitSap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short ELISA kitGM2A ELISA kit |
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Information sourced from Uniprot.org