Human Glutathione Peroxidase 1/GPX1 (U49C) protein (Recombinant) (His-Tag) (STJP017397)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Glutathione Peroxidase 1/GPX1 (U49C)-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 30% Glycerol, 100mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPX1 |
| Gene ID | 2876 |
| Uniprot ID | GPX1_HUMAN |
| Accession Number | NP_000572.2 |
| Immunogen | Human |
| Immunogen Region | 1-203aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in platelets (at protein level). |
| Post Translational Modifications | During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. |
| Function | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. |
| Protein Name | Glutathione Peroxidase 1Gpx-1Gshpx-1Cellular Glutathione PeroxidasePhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-3299685 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Protein Names | Glutathione Peroxidase 1 proteinGpx-1 proteinGshpx-1 proteinCellular Glutathione Peroxidase proteinPhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 proteinGPX1 protein |
Information sourced from Uniprot.org