Human GITR Ligand/TNFSF18 protein (Recombinant) (C-hFc) (STJP002766)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human GITR Ligand/TNFSF18 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln50-Ser177) of human GITR Ligand/TNFSF18 (Accession #NP_005083.2) fused with a hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human GITR Ligand/TNFSF18-C-hFc protein was developed in hek293 cells using the region Gln50-Ser177. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | TNFSF18 |
| Gene ID | 8995 |
| Uniprot ID | TNF18_HUMAN |
| Immunogen | Recombinant Human GITR Ligand/TNFSF18 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln50-Ser177) of human GITR Ligand/TNFSF18 (Accession #NP_005083.2) fused with a hFc tag at the C-terminus. |
| Immunogen Region | Gln50-Ser177 |
| Immunogen Sequence | QLETAKEPCMAKFGPLPSKW QMASSEPPCVNKVSDWKLEI LQNGLYLIYGQVAPNANYND VAPFEVRLYKNKDMIQTLTN KSKIQNVGGTYELHVGDTID LIFNSEHQVLKNNTYWGIIL LANPQFIS |
Additional Info
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Tumor Necrosis Factor Ligand Superfamily Member 18 proteinActivation-Inducible Tnf-Related Ligand proteinAitrl proteinGlucocorticoid-Induced Tnf-Related Ligand proteinHgitrl proteinTNFSF18 proteinAITRL proteinGITRL proteinTL6 proteinUNQ149 proteinPRO175 protein |
Information sourced from Uniprot.org