Human GIMAP5 protein (Recombinant) (His-Tag) (STJP018422)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GIMAP5-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 2mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GIMAP5 |
| Gene ID | 55340 |
| Uniprot ID | GIMA5_HUMAN |
| Accession Number | NP_060854 |
| Immunogen | Human |
| Immunogen Region | 1-284aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed with high levels in lymph node and spleen. High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes. Very low expression levels in B-lymphocytes. |
| Function | Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Is a regulator of liver endothelial cell homeostasis. |
| Protein Name | Gtpase Imap Family Member 5Immune-Associated Nucleotide-Binding Protein 5Immunity-Associated Nucleotide 4-Like 1 ProteinImmunity-Associated Nucleotide 5 ProteinIan-5Hian5Immunity-Associated Protein 3 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Iv Membrane ProteinEndosomeMultivesicular Body MembraneEndosome MembraneThe Mitochondrial Localization Originally Reported Was Observed With C-Terminally Tagged Protein And Was Not Confirmed In Later Publications |
| Alternative Protein Names | Gtpase Imap Family Member 5 proteinImmune-Associated Nucleotide-Binding Protein 5 proteinImmunity-Associated Nucleotide 4-Like 1 Protein proteinImmunity-Associated Nucleotide 5 Protein proteinIan-5 proteinHian5 proteinImmunity-Associated Protein 3 proteinGIMAP5 proteinIAN4L1 proteinIAN5 proteinIMAP3 protein |
Information sourced from Uniprot.org