Human GILT/IFI30 protein (Recombinant) (His-Tag) (STJP017861)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GILT/IFI30-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFI30 |
| Gene ID | 10437 |
| Uniprot ID | GILT_HUMAN |
| Accession Number | NP_006323 |
| Immunogen | Human |
| Immunogen Region | 58-232aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | N-glycosylated. Sugar chains contain mannose-6-phosphate. Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases. |
| Function | Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. |
| Protein Name | Gamma-Interferon-Inducible Lysosomal Thiol ReductaseGamma-Interferon-Inducible Protein Ip-30Legumaturain |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-877300 |
| Cellular Localisation | SecretedLysosome |
| Alternative Protein Names | Gamma-Interferon-Inducible Lysosomal Thiol Reductase proteinGamma-Interferon-Inducible Protein Ip-30 proteinLegumaturain proteinIFI30 proteinGILT proteinIP30 protein |
Information sourced from Uniprot.org