Human GFRA2 protein (Recombinant-Active) (C-His) (STJP011713)

Name: Human GFRA2 protein (Recombinant-Active) (C-His) (STJP011713)
SKU: STJP011713-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP011713-100

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Short Description	Recombinant-Active-Human GFRA2-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Dilution Range	Reconstitute in sterile water for a stock solution.
Formulation	Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	<0.1 EU/Mu g of the protein by the LAL method.
Immunoreactivity	Immobilised recombinant human Neurturin at 5 Mu g/mL (100 Mu L/well) can bind recombinant human GFRA2, the EC50 of human GFRA2 is 1.82 Mu g/mL.

Function	Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
Protein Name	Gdnf Family Receptor Alpha-2 Gdnf Receptor Alpha-2 Gdnfr-Alpha-2 Gfr-Alpha-2 Gdnf Receptor Beta Gdnfr-Beta Neurturin Receptor Alpha Nrtnr-Alpha Ntnr-Alpha Ret Ligand 2 Tgf-Beta-Related Neurotrophic Factor Receptor 2
Database Links	Reactome: R-HSA-419037 Reactome: R-HSA-5673001 Reactome: R-HSA-8853659
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor
Alternative Protein Names	Gdnf Family Receptor Alpha-2 protein Gdnf Receptor Alpha-2 protein Gdnfr-Alpha-2 protein Gfr-Alpha-2 protein Gdnf Receptor Beta protein Gdnfr-Beta protein Neurturin Receptor Alpha protein Nrtnr-Alpha protein Ntnr-Alpha protein Ret Ligand 2 protein Tgf-Beta-Related Neurotrophic Factor Receptor 2 protein GFRA2 protein GDNFRB protein RETL2 protein TRNR2 protein

Information sourced from Uniprot.org