Human GDF5 protein (Recombinant) (Tag free) (STJP014504)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GDF5-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 4mM HCl. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | GDF5 |
| Gene ID | 8200 |
| Uniprot ID | GDF5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala382-Arg501 |
Additional Info
| Function | Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. |
| Protein Name | Growth/Differentiation Factor 5Gdf-5Bone Morphogenetic Protein 14Bmp-14Cartilage-Derived Morphogenetic Protein 1Cdmp-1Lipopolysaccharide-Associated Protein 4Lap-4Lps-Associated Protein 4Radotermin |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedCell Membrane |
| Alternative Protein Names | Growth/Differentiation Factor 5 proteinGdf-5 proteinBone Morphogenetic Protein 14 proteinBmp-14 proteinCartilage-Derived Morphogenetic Protein 1 proteinCdmp-1 proteinLipopolysaccharide-Associated Protein 4 proteinLap-4 proteinLps-Associated Protein 4 proteinRadotermin proteinGDF5 proteinBMP14 proteinCDMP1 protein |
Information sourced from Uniprot.org