Human GATM protein (Recombinant) (His-Tag) (STJP017561)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human GATM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 10% Glycerol, 200mM NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GATM |
| Gene ID | 2628 |
| Uniprot ID | GATM_HUMAN |
| Accession Number | NP_001473.1 |
| Immunogen | Human |
| Immunogen Region | 38-423aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues. |
| Function | Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable). |
| Protein Name | Glycine Amidinotransferase - MitochondrialL-Arginine -Glycine AmidinotransferaseTransamidinase |
| Database Links | Reactome: R-HSA-71288 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembranePeripheral Membrane ProteinIntermembrane SideProbably Attached To The Outer Side Of The Inner MembraneIsoform 2: Cytoplasm |
| Alternative Protein Names | Glycine Amidinotransferase - Mitochondrial proteinL-Arginine -Glycine Amidinotransferase proteinTransamidinase proteinGATM proteinAGAT protein |
Information sourced from Uniprot.org