Human GARS protein (Recombinant) (His-Tag) (STJP018852)

Name: Human GARS protein (Recombinant) (His-Tag) (STJP018852)
SKU: STJP018852
Availability: InStock

⇓ Datasheet ⇓ SDS Citations

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP018852

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Short Description	Recombinant-Human GARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	0.5 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol	GARS1
Gene ID	2617
Uniprot ID	GARS_HUMAN
Accession Number	NP_002038
Immunogen	Human
Immunogen Region	43-289aa
Immunogen Sequence	PISLPAA ASRSSMDGAG AEEVLAPLRL AVRQQGDLVR KLKEDKAPQV DVDKAVAELK ARKRVLEAKE LALQPKDDIV DRAKMEDTLK RRFFYDQAFA IYGGVSGLYD FGPVGCALKN NIIQTWRQHF IQEEQILEID CTMLTPEPVL KTSGHVDKFA DFMVKDVKNG ECFRADHLLK AHLQKLMSDK KCSVEKKSEM ESVLAQ

Tissue Specificity	Widely expressed, including in brain and spinal cord. Isoform 2: Expressed in brain, spinal cord, muscle, heart and spleen. Isoform 1: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
Function	Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Protein Name	Glycine--Trna Ligase Diadenosine Tetraphosphate Synthetase Ap4a Synthetase Glycyl-Trna Synthetase Glyrs Glycyl-Trna Synthetase 1
Database Links	Reactome: R-HSA-379716 Reactome: R-HSA-379726
Cellular Localisation	Cytoplasm Cell Projection Axon Secreted Extracellular Exosome In Transfected Cos7 Cells Not Detected In Mitochondria Nor In Golgi Apparatus Secreted By Motor Neuron Possibly Through The Exosome Pathway Isoform 1: Mitochondrion Isoform 2: Cytoplasm
Alternative Protein Names	Glycine--Trna Ligase protein Diadenosine Tetraphosphate Synthetase protein Ap4a Synthetase protein Glycyl-Trna Synthetase protein Glyrs protein Glycyl-Trna Synthetase 1 protein GARS1 protein GARS protein

Information sourced from Uniprot.org