Human gamma-Synuclein protein (Recombinant) (No-Tag) (STJP019777)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human gamma-Synuclein-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | SNCG |
| Gene ID | 6623 |
| Uniprot ID | SYUG_HUMAN |
| Accession Number | NP_003078.2 |
| Immunogen | Human |
| Immunogen Region | 1-127aa |
| Immunogen Sequence | MDVFKKGFSI AKEGVVGAVE KTKQGVTEAA EKTKEGVMYV GAKTKENVVQ SVTSVAEKTK EQANAVSEAV VSSVNTVATK TVEEAENIAV TSGVVRKEDL RPSAPQQEGV ASKEKEEVAE EAQSGGD |
Additional Info
| Tissue Specificity | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. |
| Protein Name | Gamma-SynucleinBreast Cancer-Specific Gene 1 ProteinPersynSynoretinSr |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleAssociated With Centrosomes In Several Interphase CellsIn Mitotic CellsLocalized To The Poles Of The Spindle |
| Alternative Protein Names | Gamma-Synuclein proteinBreast Cancer-Specific Gene 1 Protein proteinPersyn proteinSynoretin proteinSr proteinSNCG proteinBCSG1 proteinPERSYN proteinPRSN protein |
Information sourced from Uniprot.org