Human Galectin-8/LGALS8 protein (Recombinant) (His-Tag) (STJP016828)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Galectin-8/LGALS8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Bioactivity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M Nacl, 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its ability to agglutinate human red blood cells. The ED50 range ≤ 10 ug/ml. |
Target Information
| Gene Symbol | LGALS8 |
| Gene ID | 3964 |
| Uniprot ID | LEG8_HUMAN |
| Accession Number | NP_963837 |
| Immunogen | Human |
| Immunogen Region | 1-317aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. |
| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Protein Names | Galectin-8 proteinGal-8 proteinPo66 Carbohydrate-Binding Protein proteinPo66-Cbp proteinProstate Carcinoma Tumor Antigen 1 proteinPcta-1 proteinLGALS8 protein |
Information sourced from Uniprot.org