Human Galectin-8/GAL8 protein (Recombinant-Active) (Tag free) (STJP012341)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human Galectin-8/GAL8-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | LGALS8 |
| Gene ID | 3964 |
| Uniprot ID | LEG8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Trp317 |
Additional Info
| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Protein Names | Galectin-8 proteinGal-8 proteinPo66 Carbohydrate-Binding Protein proteinPo66-Cbp proteinProstate Carcinoma Tumor Antigen 1 proteinPcta-1 proteinLGALS8 protein |
Information sourced from Uniprot.org