Human Galectin-10/LGALS10 protein (Recombinant) (His-Tag) (STJP017170)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Galectin-10/LGALS10-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLC |
| Gene ID | 1178 |
| Uniprot ID | LEG10_HUMAN |
| Accession Number | NP_001819.2 |
| Immunogen | Human |
| Immunogen Region | 1-142aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level). |
| Function | Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). |
| Protein Name | Galectin-10Gal-10Charcot-Leyden Crystal ProteinClcEosinophil LysophospholipaseLysolecithin Acylhydrolase |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolCytoplasmic GranuleLocalized In Granules From Where It May Be Secreted Or Transported To Other Locations In The Cell |
| Alternative Protein Names | Galectin-10 proteinGal-10 proteinCharcot-Leyden Crystal Protein proteinClc proteinEosinophil Lysophospholipase proteinLysolecithin Acylhydrolase proteinCLC proteinLGALS10 proteinLGALS10A protein |
Information sourced from Uniprot.org