Human GAK protein (Recombinant) (C-His) (STJP014257)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GAK-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | GAK |
| Gene ID | 2580 |
| Uniprot ID | GAK_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro14-Val351 |
Additional Info
| Function | Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly. |
| Protein Name | Cyclin-G-Associated KinaseDnaj Homolog Subfamily C Member 26 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusTrans-Golgi NetworkCell JunctionFocal AdhesionCytoplasmic VesicleClathrin-Coated VesicleLocalizes To The Perinuclear Area And To The Trans-Golgi NetworkAlso Seen On The Plasma MembraneProbably At Focal AdhesionsRecruitment To Clathrin-Coated Vesicles Depends On Temporal Variations In Phosphoinositide Composition Of Clathrin-Coated Vesicles |
| Alternative Protein Names | Cyclin-G-Associated Kinase proteinDnaj Homolog Subfamily C Member 26 proteinGAK proteinDNAJC26 protein |
Information sourced from Uniprot.org