Human GADD45GIP1 protein (Recombinant) (N-His) (STJP008294)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GADD45GIP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | GADD45GIP1 |
| Gene ID | 90480 |
| Uniprot ID | G45IP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr47-Ser222 |
Additional Info
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
| Protein Name | Large Ribosomal Subunit Protein Ml6439s Ribosomal Protein L59 - MitochondrialMrp-L59Ckii Beta-Associating ProteinCr6-Interacting Factor 1Crif1Growth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1Papillomavirus L2-Interacting Nuclear Protein 1PlinpPlinp-1P53-Responsive Gene 6 Protein |
| Database Links | Reactome: R-HSA-5368286Reactome: R-HSA-5389840Reactome: R-HSA-5419276 |
| Cellular Localisation | MitochondrionNucleusUsing N-Terminally Tagged ConstructsHas Been Found In The NucleusC-Terminally Tagged Constructs Are Targeted Exclusively To MitochondriaThis Discrepancy May Be Explained By Masking Of A Potential N-Terminal Mitochondrial Targeting Signal By The Tag |
| Alternative Protein Names | Large Ribosomal Subunit Protein Ml64 protein39s Ribosomal Protein L59 - Mitochondrial proteinMrp-L59 proteinCkii Beta-Associating Protein proteinCr6-Interacting Factor 1 proteinCrif1 proteinGrowth Arrest And Dna Damage-Inducible Proteins-Interacting Protein 1 proteinPapillomavirus L2-Interacting Nuclear Protein 1 proteinPlinp proteinPlinp-1 proteinP53-Responsive Gene 6 Protein proteinGADD45GIP1 proteinMRPL59 proteinPLINP1 proteinPRG6 protein |
Information sourced from Uniprot.org