Human FUT6 protein (Recombinant) (N-His) (STJP004893)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FUT6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FUT6 |
| Gene ID | 2528 |
| Uniprot ID | FUT6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg35-Thr359 |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage releases a secreted glycoform of 43 kDa. |
| Function | Isoform 1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates. Isoform 2: Does not have alpha(1,3)-fucosyltransferase activity. |
| Protein Name | 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6Fucosyltransferase 6Fucosyltransferase ViFuc-TviFuct-ViGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Protein Names | 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6 proteinFucosyltransferase 6 proteinFucosyltransferase Vi proteinFuc-Tvi proteinFuct-Vi proteinGalactoside 3-L-Fucosyltransferase proteinFUT6 proteinFCT3A protein |
Information sourced from Uniprot.org