Human FUT4 (Fucosyltransferase 4) Sandwich ELISA Kit (STJE0009008)
SPECIFICATIONS
General Information
| Short Description | This FUT4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.062ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | FUT4 |
| Gene ID | 2526 |
| Uniprot ID | FUT4_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Isoform Short: Expressed at low levels in bone marrow-derived mesenchymal stem cells. Expressed in cord blood immature promyelocytes and in peripheral blood myeloid and lymphoid cell populations. |
| Post Translational Modifications | |
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 44-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-FucosyltransferaseElam-1 Ligand FucosyltransferaseFucosyltransferase 4Fucosyltransferase IvFuc-TivFuct-IvGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative ELISA Names | Alpha-(1 -3-Fucosyltransferase 4 ELISA kit4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase ELISA kitElam-1 Ligand Fucosyltransferase ELISA kitFucosyltransferase 4 ELISA kitFucosyltransferase Iv ELISA kitFuc-Tiv ELISA kitFuct-Iv ELISA kitGalactoside 3-L-Fucosyltransferase ELISA kitFUT4 ELISA kitELFT ELISA kitFCT3A ELISA kit |
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Information sourced from Uniprot.org