| Function | RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells. Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs. Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase FtoFat Mass And Obesity-Associated ProteinU6 Small Nuclear Rna2'-O-Methyladenosine-N(6--Demethylase FtoU6 Small Nuclear Rna N(6-Methyladenosine-Demethylase FtoMrna2'-O-Methyladenosine-N(6--Demethylase FtoM6a(M-Demethylase FtoMrna N(6-Methyladenosine Demethylase FtoTrna N1-Methyl Adenine Demethylase Fto |
| Database Links | Reactome: R-HSA-73943 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmLocalizes Mainly In The NucleusWhere It Is Able To Demethylate N(6)-Methyladenosine (M6a) And N(6)2'-O-Dimethyladenosine Cap (M6a(M)) In U6 Small Nuclear Rna (Snrna)N(1)-Methyladenine From Trnas And Internal M6a In MrnasIn The CytoplasmMediates Demethylation Of M6a And M6a(M) In Mrnas And N(1)-Methyladenine From Trnas |
| Alternative Protein Names | Alpha-Ketoglutarate-Dependent Dioxygenase Fto proteinFat Mass And Obesity-Associated Protein proteinU6 Small Nuclear Rna protein2'-O-Methyladenosine-N(6--Demethylase Fto proteinU6 Small Nuclear Rna N(6-Methyladenosine-Demethylase Fto proteinMrna protein2'-O-Methyladenosine-N(6--Demethylase Fto proteinM6a(M-Demethylase Fto proteinMrna N(6-Methyladenosine Demethylase Fto proteinTrna N1-Methyl Adenine Demethylase Fto proteinFTO proteinKIAA1752 protein |
Information sourced from Uniprot.org
