Human FSTL3/FLRG protein (Recombinant-Active) (C-His) (STJP011756)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human FSTL3/FLRG-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to neutralize Activinmediated erythroid differentiation of human chronic myelogenous leukemia cells (K562). The ED50 for this effect is 3-15 ng/mL in the presence of 7.5 ng/mL recombinant human Activin A. |
Target Information
| Gene Symbol | FSTL3 |
| Gene ID | 10272 |
| Uniprot ID | FSTL3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met27-Val263 |
Additional Info
| Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiation. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| Protein Name | Follistatin-Related Protein 3Follistatin-Like Protein 3Follistatin-Related Gene Protein |
| Database Links | Reactome: R-HSA-2473224Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: NucleusAlthough Alternative Initiation Has Been Demonstrated And Resulted In Different LocalizationThe Major Source Of Nuclear Fstl3 Appears Not To Depend On Translation Initiation At Met-27 According To |
| Alternative Protein Names | Follistatin-Related Protein 3 proteinFollistatin-Like Protein 3 proteinFollistatin-Related Gene Protein proteinFSTL3 proteinFLRG proteinUNQ674 proteinPRO1308 protein |
Information sourced from Uniprot.org