| Short Description : | Recombinant-Human FRK-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | FRK |
| Gene ID: | 2444 |
| Uniprot ID: | FRK_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Ile234-Phe491 |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Kinase FrkFyn-Related KinaseNuclear Tyrosine Protein Kinase RakProtein-Tyrosine Kinase 5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusPredominantly Found In The NucleusWith A Small Fraction Found In The Cell Periphery |
| Alternative Protein Names | Tyrosine-Protein Kinase Frk proteinFyn-Related Kinase proteinNuclear Tyrosine Protein Kinase Rak proteinProtein-Tyrosine Kinase 5 proteinFRK proteinPTK5 proteinRAK protein |
Information sourced from Uniprot.org