Human FOXA2 (FOXA2) Antibody Pair (STJAP00774)
SPECIFICATIONS
ClonalityMonoclonal/Monoclonal
HostRabbit/Rabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein
General Information
| Short Description | This FOXA2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R56-1R-9/R87-3V-7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FOXA2 |
| Gene ID | 3170 |
| Uniprot ID | FOXA2_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Post Translational Modifications | Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Protein Name | Hepatocyte Nuclear Factor 3-BetaHnf-3-BetaHnf-3bForkhead Box Protein A2Transcription Factor 3bTcf-3b |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-9796292Reactome: R-HSA-9823730Reactome: R-HSA-9925561 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent MannerIn Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus |
| Alternative Antibody Pair Names | Hepatocyte Nuclear Factor 3-Beta antibody pairHnf-3-Beta antibody pairHnf-3b antibody pairForkhead Box Protein A2 antibody pairTranscription Factor 3b antibody pairTcf-3b antibody pairFOXA2 antibody pairHNF3B antibody pairTCF3B antibody pair |
Information sourced from Uniprot.org