Tissue Specificity | Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. |
Post Translational Modifications | N-glycosylated. |
Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. |
Protein Name | Folate Receptor BetaFr-BetaFolate Receptor 2Folate Receptor - Fetal/PlacentalPlacental Folate-Binding ProteinFbp |
Database Links | Reactome: R-HSA-163125Reactome: R-HSA-196757 |
Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecreted |
Alternative ELISA Names | Folate Receptor Beta ELISA kitFr-Beta ELISA kitFolate Receptor 2 ELISA kitFolate Receptor - Fetal/Placental ELISA kitPlacental Folate-Binding Protein ELISA kitFbp ELISA kitFOLR2 ELISA kit |
output | |
Information sourced from Uniprot.org