Human FOLR1 (Folate Receptor Alpha) Antibody Pair (STJAP00397)
General Information
| Short Description | This FOLR1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | FOLR1 |
| Gene ID | 2348 |
| Uniprot ID | FOLR1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human FOLR1 protien.Detection Immunogen: Recombinant Human FOLR1 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Pair Names | Folate Receptor Alpha antibody pairFr-Alpha antibody pairAdult Folate-Binding Protein antibody pairFbp antibody pairFolate Receptor 1 antibody pairFolate Receptor - Adult antibody pairKb Cells Fbp antibody pairOvarian Tumor-Associated Antigen Mov18 antibody pairFOLR1 antibody pairFOLR antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human FOLR1 (Folate Receptor Alpha) Antibody Pair (STJAP00397)
This antibody pair detects human FOLR1 (Folate Receptor Alpha), corresponding to UniProt entry P15328. Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated and the detection antibody is biotin-conjugated. Both are provided at 0.5 mg/mL and were raised in goat using recombinant human FOLR1 protein as the immunogen.
This pair is validated for use in ELISA. Recommended sample types include serum, plasma, and other biological fluids.
Both the capture and detection antibodies were purified by antigen affinity chromatography. The capture antibody is formulated in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.5, while the detection antibody formulation additionally contains 1% protective protein.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.