This human FNDC5 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes in serum, plasma and other biological fluids.
Applications
CLIA
Reactivity
Human
Sensitivity
4.69pg/mL
Detection Limit
7.81~500pg/mL
Note
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Product Properties
Storage Instruction
If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
This kit recognizes Human FNDC5 in samples. No significant cross-reactivity or interference between Human FNDC5 and analogues was observed.
Sample Type
Serum, plasma and other biological fluids
Additional Info
Tissue Specificity
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Post Translational Modifications
The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated.
Function
Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Protein Name
Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin
Database Links
Cellular Localisation
Fibronectin Type Iii Domain-Containing Protein 5: Cell MembraneSingle-Pass Membrane ProteinPeroxisome MembraneImported Into Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In Plasma Following Endurance Exercise
Alternative CLIA Names
Fibronectin Type Iii Domain-Containing Protein 5 CLIA kitFibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin CLIA kitFNDC5 CLIA kitFRCP2 CLIA kit
Specificity
This kit recognizes Human FNDC5 in samples. No significant cross-reactivity or interference between Human FNDC5 and analogues was observed.
