| Post Translational Modifications | N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. |
| Function | Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina. Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members. Promotes neurite outgrowth (in vitro). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt3Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3 |
| Database Links | Reactome: R-HSA-376176Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell JunctionFocal AdhesionSecretedCell ProjectionAxonGrowth Cone MembraneDetected On Dendritic Punctae That Colocalize In Part With Glutamaergic SynapsesBut Not With Gabaergic SynapsesProteolytic Cleavage In The Juxtamembrane Region Gives Rise To A Shedded Ectodomain |
| Alternative Protein Names | Leucine-Rich Repeat Transmembrane Protein Flrt3 proteinFibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3 proteinFLRT3 proteinKIAA1469 proteinUNQ856 proteinPRO1865 protein |
Information sourced from Uniprot.org
