| Post Translational Modifications | N-glycosylated. Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. |
| Function | Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt1Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 |
| Database Links | Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmic Vesicle MembraneCytoplasmPerinuclear RegionCell JunctionFocal AdhesionSecretedCell ProjectionNeuron ProjectionIn Addition To Its Location At The Cell MembraneColocalizes With Fgfr1 In Punctate Perinuclear Cytoplasmic VesiclesDetected Along Neurites And At Contacts Between Neurite Termini And Other CellsProteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Protein Names | Leucine-Rich Repeat Transmembrane Protein Flrt1 proteinFibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 proteinFLRT1 proteinUNQ752 proteinPRO1483 protein |
Information sourced from Uniprot.org
