Human FLIP/CFLAR protein (Recombinant) (N-His) (STJP006542)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FLIP/CFLAR-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | CFLAR |
| Gene ID | 8837 |
| Uniprot ID | CFLAR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp31-Asn184 |
Additional Info
| Post Translational Modifications | Proteolytically processed by CASP8 generating subunit p43 and p12. |
| Function | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
| Protein Name | Casp8 And Fadd-Like Apoptosis RegulatorCaspase HomologCashCaspase-Eight-Related ProteinCasperCaspase-Like Apoptosis Regulatory ProteinClarpCellular Flice-Like Inhibitory ProteinC-FlipFadd-Like Antiapoptotic Molecule 1Flame-1Inhibitor Of FliceI-FliceMach-Related Inducer Of ToxicityMritUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 |
| Database Links | Reactome: R-HSA-3371378 O15519-1Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357905 O15519-1Reactome: R-HSA-69416 O15519-2Reactome: R-HSA-75158 |
| Cellular Localisation | |
| Alternative Protein Names | Casp8 And Fadd-Like Apoptosis Regulator proteinCaspase Homolog proteinCash proteinCaspase-Eight-Related Protein proteinCasper proteinCaspase-Like Apoptosis Regulatory Protein proteinClarp proteinCellular Flice-Like Inhibitory Protein proteinC-Flip proteinFadd-Like Antiapoptotic Molecule 1 proteinFlame-1 proteinInhibitor Of Flice proteinI-Flice proteinMach-Related Inducer Of Toxicity proteinMrit proteinUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 proteinCFLAR proteinCASH proteinCASP8AP1 proteinCLARP proteinMRIT protein |
Information sourced from Uniprot.org