Human FLG2 protein (Recombinant) (N-His) (STJP005545)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FLG2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FLG2 |
| Gene ID | 388698 |
| Uniprot ID | FILA2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu1222-Gln1368 |
Additional Info
| Post Translational Modifications | Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers. |
| Function | Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. |
| Protein Name | Filaggrin-2Flg-2Intermediate Filament-Associated And Psoriasis-Susceptibility ProteinIfapsoriasin |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoplasmic GranuleIn The Stratum Corneum Of The EpidermisDispersed Diffusely Throughout The CytoplasmWhile In The Stratum GranulosumLocalized Within Keratohyalin GranulesIn Granular Keratinocytes And In Lower CorneocytesColocalizes With Calpain-1/Capn1 |
| Alternative Protein Names | Filaggrin-2 proteinFlg-2 proteinIntermediate Filament-Associated And Psoriasis-Susceptibility Protein proteinIfapsoriasin proteinFLG2 proteinIFPS protein |
Information sourced from Uniprot.org