Human FKBP6 protein (Recombinant) (N-His) (STJP010728)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FKBP6-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FKBP6 |
| Gene ID | 8468 |
| Uniprot ID | FKBP6_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser20-Ser327 |
Additional Info
| Function | Has an essential role in spermatogenesis. It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. |
| Protein Name | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6Inactive Ppiase Fkbp636 Kda Fk506-Binding Protein36 Kda FkbpFkbp-36Fk506-Binding Protein 6Fkbp-6Immunophilin Fkbp36 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmNucleusIn SpermatocytesIt Colocalizes With Piwil1 In Large Cytoplasmic GranulesDoes Not Localize To The Synaptonemal Complex |
| Alternative Protein Names | Inactive Peptidyl-Prolyl Cis-Trans Isomerase Fkbp6 proteinInactive Ppiase Fkbp6 protein36 Kda Fk506-Binding Protein protein36 Kda Fkbp proteinFkbp-36 proteinFk506-Binding Protein 6 proteinFkbp-6 proteinImmunophilin Fkbp36 proteinFKBP6 proteinFKBP36 protein |
Information sourced from Uniprot.org