Human FKBP52/FKBP4 protein (Recombinant) (His-Tag) (STJP016450)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FKBP52/FKBP4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Enzyme Activity |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity | Specific activity is > 700nmol/min/mg, and is defined as the amount of cleaves 1nmole of suc-AAPF-pNA per minute at 37C in Tris-HCl pH 8.0 using chymotrypsin. |
Target Information
| Gene Symbol | FKBP4 |
| Gene ID | 2288 |
| Uniprot ID | FKBP4_HUMAN |
| Accession Number | NP_002005.1 |
| Immunogen | Human |
| Immunogen Region | 1-459aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation by CK2 results in loss of HSP90 binding activity. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4Ppiase Fkbp451 Kda Fk506-Binding ProteinFkbp5152 Kda Fk506-Binding Protein52 Kda FkbpFkbp-5259 Kda ImmunophilinP59Fk506-Binding Protein 4Fkbp-4Fkbp59Hsp-Binding ImmunophilinHbiImmunophilin Fkbp52Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-3371568Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | CytoplasmCytosolMitochondrionNucleusCytoskeletonCell ProjectionAxonShuttles From Mitochondria To NucleusCo-Localizes In Mitochondria With The Glucocorticoid ReceptorColocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons |
| Alternative Protein Names | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 proteinPpiase Fkbp4 protein51 Kda Fk506-Binding Protein proteinFkbp51 protein52 Kda Fk506-Binding Protein protein52 Kda Fkbp proteinFkbp-52 protein59 Kda Immunophilin proteinP59 proteinFk506-Binding Protein 4 proteinFkbp-4 proteinFkbp59 proteinHsp-Binding Immunophilin proteinHbi proteinImmunophilin Fkbp52 proteinRotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed proteinFKBP4 proteinFKBP52 protein |
Information sourced from Uniprot.org