Human FGF-9 protein (Recombinant) (C-His) (STJP002974)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human FGF-9 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala2-Ser208) of human FGF-9 (Accession #NP_002001.1) fused with no additional amino acid.
General Information
| Short Description | Recombinant-Human FGF-9-C-His protein was developed in hek293 cells using the region Ala2-Ser208. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of 20mM PB, pH 6.0. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured in a cell proliferation assay using BALB/3T3 mouse fibroblasts. The ED50 for this effect is 2.34-9.34 ng/mL, corresponding to a specific activity of 1.07×105~4.27×105 units/mg. |
| Determination Method | <1 EU/Mu g |
Target Information
| Gene Symbol | FGF9 |
| Gene ID | 2254 |
| Uniprot ID | FGF9_HUMAN |
| Immunogen | Recombinant Human FGF-9 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala2-Ser208) of human FGF-9 (Accession #NP_002001.1) fused with no additional amino acid. |
| Immunogen Region | Ala2-Ser208 |
| Immunogen Sequence | PTDPLSLQELRREFTVSLYL ARKLLSEVQGYVHSFAESRL PGVNLDLLPLGYHLPNVSLT FQAWHHLSDSERLCFLATTL RPFPAMLGGLGTQGTWTSSE REQLWAMRLDLRDLHRHLRF QVLAAGFKCSKEEEDKEEEE EEEEEEKKLPLGALGGPNQV SSQVSWPQLLYTYQLLHSLE LVLSRAVRDLLLLSLPRRPG SAWDS |
Additional Info
| Tissue Specificity | Glial cells. |
| Post Translational Modifications | Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step. N-glycosylated. |
| Function | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. |
| Protein Name | Fibroblast Growth Factor 9Fgf-9Glia-Activating FactorGafHeparin-Binding Growth Factor 9Hbgf-9 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1839122Reactome: R-HSA-1839130Reactome: R-HSA-190322Reactome: R-HSA-190371Reactome: R-HSA-190372Reactome: R-HSA-190373Reactome: R-HSA-190375Reactome: R-HSA-2033519Reactome: R-HSA-2219530Reactome: R-HSA-5654219Reactome: R-HSA-5654221Reactome: R-HSA-5654227Reactome: R-HSA-5654228Reactome: R-HSA-5654687Reactome: R-HSA-5654688Reactome: R-HSA-5654689Reactome: R-HSA-5654693Reactome: R-HSA-5654695Reactome: R-HSA-5654699Reactome: R-HSA-5654700Reactome: R-HSA-5654704Reactome: R-HSA-5654706Reactome: R-HSA-5654710Reactome: R-HSA-5654712Reactome: R-HSA-5654719Reactome: R-HSA-5654720Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-5655253Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Fibroblast Growth Factor 9 proteinFgf-9 proteinGlia-Activating Factor proteinGaf proteinHeparin-Binding Growth Factor 9 proteinHbgf-9 proteinFGF9 protein |
Information sourced from Uniprot.org