Human Fetuin A/AHSG protein (Recombinant) (C-His) (STJP000968)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Fetuin A/AHSG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala19-Val367) of human Fetuin-A/AHSG/FETUA (Accession #NP_001613.2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Fetuin A/AHSG-C-His protein was developed in hek293 cells using the region Ala19-Val367. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | 1.Measured by its ability to inhibit calcium phosphate precipitation. The IC50 value is <25 Mu g/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | AHSG |
| Gene ID | 197 |
| Uniprot ID | FETUA_HUMAN |
| Immunogen | Recombinant Human Fetuin A/AHSG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala19-Val367) of human Fetuin-A/AHSG/FETUA (Accession #NP_001613.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Ala19-Val367 |
| Immunogen Sequence | APHGPGLIYRQPNCDDPETE EAALVAIDYINQNLPWGYKH TLNQIDEVKVWPQQPSGELF EIEIDTLETTCHVLDPTPVA RCSVRQLKEHAVEGDCDFQL LKLDGKFSVVYAKCDSSPDS AEDVRKVCQDCPLLAPLNDT RVVHAAKAALAAFNAQNNGS NFQLEEISRAQLVPLPPSTY VEFTVSGTDCVAKEATEAAK CNLLAEKQYGFCKATLSEKL GGAEVAVTCMVFQTQPVSS |
Additional Info
| Tissue Specificity | Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. O- and N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan at Asn-156: Hex5HexNAc4.N-glycan heterogeneity at Asn-176: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor). |
| Function | Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. |
| Protein Name | Alpha-2-Hs-GlycoproteinAlpha-2-Z-GlobulinBa-Alpha-2-GlycoproteinFetuin-A Cleaved Into - Alpha-2-Hs-Glycoprotein Chain A - Alpha-2-Hs-Glycoprotein Chain B |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-6798695Reactome: R-HSA-8957275 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Alpha-2-Hs-GlycoproteinAlpha-2-Z-Globulin proteinBa-Alpha-2-GlycoproteinFetuin-A Cleaved Into - Alpha-2-Hs-Glycoprotein Chain A - Alpha-2-Hs-Glycoprotein Chain B proteinAHSG proteinFETUA proteinPRO2743 protein |
Information sourced from Uniprot.org