Human FERMT2 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007431)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FERMT2-N-His-SUMO & C-Strep protein was developed from e.coli for the region N-His-SUMO & C-Strep. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FERMT2 |
| Gene ID | 10979 |
| Uniprot ID | FERM2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro373-Lys497 |
Additional Info
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2Kindlin-2Mitogen-Inducible Gene 2 ProteinMig-2Pleckstrin Homology Domain-Containing Family C Member 1Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonStress FiberCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneNucleusMyofibrilSarcomereI BandCell SurfaceColocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion SitesColocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading CellsBinds To Membranes That Contain Phosphatidylinositides |
| Alternative Protein Names | Fermitin Family Homolog 2 proteinKindlin-2 proteinMitogen-Inducible Gene 2 Protein proteinMig-2 proteinPleckstrin Homology Domain-Containing Family C Member 1 proteinPh Domain-Containing Family C Member 1 proteinFERMT2 proteinKIND2 proteinMIG2 proteinPLEKHC1 protein |
Information sourced from Uniprot.org