| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2Kindlin-2Mitogen-Inducible Gene 2 ProteinMig-2Pleckstrin Homology Domain-Containing Family C Member 1Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonStress FiberCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneNucleusMyofibrilSarcomereI BandCell SurfaceColocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion SitesColocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading CellsBinds To Membranes That Contain Phosphatidylinositides |
| Alternative Protein Names | Fermitin Family Homolog 2 proteinKindlin-2 proteinMitogen-Inducible Gene 2 Protein proteinMig-2 proteinPleckstrin Homology Domain-Containing Family C Member 1 proteinPh Domain-Containing Family C Member 1 proteinFERMT2 proteinKIND2 proteinMIG2 proteinPLEKHC1 protein |
Information sourced from Uniprot.org
