Human FcRn/FCGRT&B2M protein (Recombinant) (C-His&Avi) {Biotin} (STJP019929)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human FcRn/FCGRT&B2M Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser297) & (Ile21-Met119) of Human FcRn/FCGRT&B2M (Accession #P55899&P61769) fused with a C-His&A
General Information
| Short Description | Recombinant-Human FcRn/FCGRT&B2M-C-His&Avi protein was developed in hek293 cells using the region Ala24-Ser297. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCGRT |
| Gene ID | 2217 |
| Uniprot ID | FCGRN_HUMAN |
| Immunogen | Biotinylated Recombinant Human FcRn/FCGRT&B2M Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala24-Ser297) & (Ile21-Met119) of Human FcRn/FCGRT&B2M (Accession #P55899&P61769) fused with a C-His&A |
| Immunogen Region | Ala24-Ser297 |
| Immunogen Sequence | AESHLSLLYHLTAVSSPAPG TPAFWVSGWLGPQQYLSYNS LRGEAEPCGAWVWENQVSWY WEKETTDLRIKEKLFLEAFK ALGGKGPYTLQGLLGCELGP DNTSVPTAKFALNGEEFMNF DLKQGTWGGDWPEALAISQR WQQQDKAANKELTFLLFSCP HRLREHLERGRGNLEWKEPP SMRLKARPSSPGFSVLTCSA FSFYPPELQLRFLRNGLAAG TGQGDFGPNSDGSFHASSS |
Additional Info
| Tissue Specificity | Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine. |
| Function | Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. |
| Protein Name | Igg Receptor Fcrn Large Subunit P51FcrnIgg Fc Fragment Receptor Transporter Alpha ChainNeonatal Fc Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndosome Membrane |
| Alternative Protein Names | Igg Receptor Fcrn Large Subunit P51 proteinFcrn proteinIgg Fc Fragment Receptor Transporter Alpha Chain proteinNeonatal Fc Receptor proteinFCGRT proteinFCRN protein |
Information sourced from Uniprot.org