Human FCHO1 protein (Recombinant) (N-His) (STJP010615)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FCHO1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FCHO1 |
| Gene ID | 23149 |
| Uniprot ID | FCHO1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser616-Cys889 |
Additional Info
| Function | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation. |
| Protein Name | F-Bar Domain Only Protein 1 |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | MembraneClathrin-Coated PitPeripheral Membrane ProteinCytoplasmic SideAssociated With Forming But Not Mature Clathrin-Coated VesiclesThe Recruitment To Coated-Pits Precede The One Of Clathrin And The Adaptor Protein Complex Ap-2It May Also Dynamically Associate With Golgi/Tgn Membranes |
| Alternative Protein Names | F-Bar Domain Only Protein 1 proteinFCHO1 proteinKIAA0290 protein |
Information sourced from Uniprot.org