Human Fc gamma RIIB/FCGR2B/CD32b protein (Recombinant) (C-His&Avi) {Biotin} (STJP019938)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human Fc gamma RIIB/FCGR2B/CD32b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala46-Pro217) of Human Fc gamma RIIB/CD32b (Accession #P31994-1) fused with a C-His&Avi ta
General Information
| Short Description | Recombinant-Human Fc gamma RIIB/FCGR2B/CD32b-C-His&Avi protein was developed in hek293 cells using the region Ala46-Pro217. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCGR2B |
| Gene ID | 2213 |
| Uniprot ID | FCG2B_HUMAN |
| Immunogen | Biotinylated Recombinant Human Fc gamma RIIB/FCGR2B/CD32b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala46-Pro217) of Human Fc gamma RIIB/CD32b (Accession #P31994-1) fused with a C-His&Avi ta |
| Immunogen Region | Ala46-Pro217 |
| Immunogen Sequence | APPKAVLKLEPQWINVLQED SVTLTCRGTHSPESDSIQWF HNGNLIPTHTQPSYRFKANN NDSGEYTCQTGQTSLSDPVH LTVLSEWLVLQTPHLEFQEG ETIVLRCHSWKDKPLVKVTF FQNGKSKKFSRSDPNFSIPQ ANHSHSGDYHCTGNIGYTLY SSKPVTITVQAP |
Additional Info
| Tissue Specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Post Translational Modifications | Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. |
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-BIgg Fc Receptor Ii-BCdw32Fc-Gamma Rii-BFc-Gamma-RiibFcrii-BCd Antigen Cd32 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B proteinIgg Fc Receptor Ii-B proteinCdw32 proteinFc-Gamma Rii-B proteinFc-Gamma-Riib proteinFcrii-B proteinCd Antigen Cd32 proteinFCGR2B proteinCD32 proteinFCG2 proteinIGFR2 protein |
Information sourced from Uniprot.org