• Biotinylated Human Fc gamma RIIB/CD32b on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human Fc gamma RIIB/CD32b is greater than 95% as determined by SEC-HPLC.
  • Rituximab captured on CM5 Chip via Protein A can bind Biotinylated Human Fc gamma RIIB, His-Avi Tag with an affinity constant of 3. 97 Mu M as determined in SPR assay (Biacore T200).

Human Fc gamma RIIB/CD32b protein (Recombinant) (C-His-Avi) {Biotin} (STJP001750)

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STJP001750

€773.13 - €2,386.88
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Fc gamma RIIB/CD32b-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: FCGR2B
Gene ID: 2213
Uniprot ID: FCG2B_HUMAN
Immunogen Region: Ala46-Pro217
Immunogen: DNA sequence encoding Human Fc gamma RIIB/CD32b including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B
Igg Fc Receptor Ii-B
Cdw32
Fc-Gamma Rii-B
Fc-Gamma-Riib
Fcrii-B
Cd Antigen Cd32
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-B protein
Igg Fc Receptor Ii-B protein
Cdw32 protein
Fc-Gamma Rii-B protein
Fc-Gamma-Riib protein
Fcrii-B protein
Cd Antigen Cd32 protein
FCGR2B protein
CD32 protein
FCG2 protein
IGFR2 protein

Information sourced from Uniprot.org

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