Human Fc-gamma RIIa/CD32a (H167R) protein (Recombinant) (C-hFc & His) (STJP002756)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Fc-gamma RIIa/CD32a (H167R) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala36-Ile218 (R167) ) of human FCGR2A/CD32a (R167) (Accession #NP_001129691.1) fused with a Fc, 6×His
General Information
| Short Description | Recombinant-Human Fc-gamma RIIa/CD32a (H167R)-C-hFc & His protein was developed in hek293 cells using the region Ala36-Ile218. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized Human FCGR2A/CD32a (R167) at 1 Mu g/mL (100 Mu L/well) can bind FCGR2A Rabbit pAb with a linear range of 0.977-175.35 ng/mL. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | FCGR2A |
| Gene ID | 2212 |
| Uniprot ID | FCG2A_HUMAN |
| Immunogen | Recombinant Human Fc-gamma RIIa/CD32a (H167R) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala36-Ile218 (R167) ) of human FCGR2A/CD32a (R167) (Accession #NP_001129691.1) fused with a Fc, 6×His |
| Immunogen Region | Ala36-Ile218 |
| Immunogen Sequence | AAPPKAVLKLEPPWINVLQE DSVTLTCQGARSPESDSIQW FHNGNLIPTHTQPSYRFKAN NNDSGEYTCQTGQTSLSDPV HLTVLSEWLVLQTPHLEFQE GETIMLRCHSWKDKPLVKVT FFQNGKSQKFSHLDPTFSIP QANHSHSGDYHCTGNIGYTL FSSKPVRITVQVPSMGSSSP MGI |
Additional Info
| Post Translational Modifications | Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK. |
| Function | Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-AIgg Fc Receptor Ii-ACdw32Fc-Gamma Rii-AFc-Gamma-RiiaFcrii-ACd Antigen Cd32 |
| Database Links | Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-6798695Reactome: R-HSA-9664323 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-A proteinIgg Fc Receptor Ii-A proteinCdw32 proteinFc-Gamma Rii-A proteinFc-Gamma-Riia proteinFcrii-A proteinCd Antigen Cd32 proteinFCGR2A proteinCD32 proteinFCG2 proteinFCGR2A1 proteinIGFR2 protein |
Information sourced from Uniprot.org