| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Fc epsilon RII/CD23-N-his protein was developed from hek293 cells and has a target region of N-his. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
FCER2 |
| Gene ID: |
2208 |
| Uniprot ID: |
FCER2_HUMAN |
| Immunogen: |
Recombinant Human Fc epsilon RII/CD23 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp 48-Ser321) of human CD23/Fc epsilon RII (Accession #NP_001993.2.) fused with a 6×His tag at the N-terminus |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorBlast-2C-Type Lectin Domain Family 4 Member JFc-Epsilon-RiiImmunoglobulin E-Binding FactorLymphocyte Ige ReceptorCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecretedAlso Exists As A Soluble Excreted FormScd23 |
| Alternative Protein Names | Low Affinity Immunoglobulin Epsilon Fc Receptor proteinBlast-2 proteinC-Type Lectin Domain Family 4 Member J proteinFc-Epsilon-Rii proteinImmunoglobulin E-Binding Factor proteinLymphocyte Ige Receptor proteinCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form proteinFCER2 proteinCD23A proteinCLEC4J proteinFCE2 proteinIGEBF protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
