Human Fc epsilon RI alpha protein (Recombinant) (C-His) (STJP001014)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Fc epsilon RI alpha Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Gln205) of human Fc epsilon RI alpha (Accession #NP_001992) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Fc epsilon RI alpha-C-His protein was developed in hek293 cells using the region Val26-Gln205. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA.Immobilized FITC anti-human Fc Epsilon RI Alpha Antibody at 1 Mu g/mL (25 Mu L/well) can bind Human Fc epsilon RI alpha with a linear range of 0.46-3.15 ng/mL. |
| Determination Method | < 0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | FCER1A |
| Gene ID | 2205 |
| Uniprot ID | FCERA_HUMAN |
| Immunogen | Recombinant Human Fc epsilon RI alpha Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Gln205) of human Fc epsilon RI alpha (Accession #NP_001992) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Val26-Gln205 |
| Immunogen Sequence | VPQKPKVSLNPPWNRIFKGE NVTLTCNGNNFFEVSSTKWF HNGSLSEETNSSLNIVNAKF EDSGEYKCQHQQVNESEPVY LEVFSDWLLLQASAEVVMEG QPLFLRCHGWRNWDVYKVIY YKDGEALKYWYENHNISITN ATVEDSGTYYCTGKVWQLDY ESEPLNITVIKAPREKYWLQ |
Additional Info
| Tissue Specificity | Expressed in eosinophils. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit AlphaFc-Epsilon Ri-AlphaFceriIge Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha proteinFc-Epsilon Ri-Alpha proteinFceri proteinIge Fc Receptor Subunit Alpha proteinFCER1A proteinFCE1A protein |
Information sourced from Uniprot.org