Human Fc Epsilon R 2/CD23 (Low Affinity Immunoglobulin Epsilon Fc Receptor) Antibody Pair (STJAP00386)
General Information
| Short Description | This Fc Epsilon R 2/CD23 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | FCER2 |
| Gene ID | 2208 |
| Uniprot ID | FCER2_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human Fc Epsilon R 2/CD23 protien.Detection Immunogen: Recombinant Human Fc Epsilon R 2/CD23 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorBlast-2C-Type Lectin Domain Family 4 Member JFc-Epsilon-RiiImmunoglobulin E-Binding FactorLymphocyte Ige ReceptorCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecretedAlso Exists As A Soluble Excreted FormScd23 |
| Alternative Antibody Pair Names | Low Affinity Immunoglobulin Epsilon Fc Receptor antibody pairBlast-2 antibody pairC-Type Lectin Domain Family 4 Member J antibody pairFc-Epsilon-Rii antibody pairImmunoglobulin E-Binding Factor antibody pairLymphocyte Ige Receptor antibody pairCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form antibody pairFCER2 antibody pairCD23A antibody pairCLEC4J antibody pairFCE2 antibody pairIGEBF antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human Fc Epsilon R 2/CD23 (Low Affinity Immunoglobulin Epsilon Fc Receptor) Antibody Pair (STJAP00386)
This antibody pair is designed to detect human Fc Epsilon R 2/CD23 (Low Affinity Immunoglobulin Epsilon Fc Receptor), corresponding to UniProt entry P06734. Reactivity is confirmed for human samples only.
The capture antibody is supplied unconjugated and the detection antibody is biotin-conjugated; both are raised in goat. Each component is provided at 0.5 mg/mL, with the capture antibody formulated in PBS containing 0.04% Proclin 300 and 50% glycerol at pH 7.5, and the detection antibody formulated in PBS containing 0.04% Proclin 300, 1% protective protein, and 50% glycerol at pH 7.5.
This pair has been validated for use in ELISA. No other assay formats are listed in the product documentation.
Both the capture and detection antibodies were raised against recombinant human Fc Epsilon R 2/CD23 protein. Both antibodies were subsequently purified by antigen affinity chromatography.
This pair is intended for use with serum, plasma, and other biological fluids. These products are for research use only and are not intended for diagnostic or therapeutic applications.
Both components should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.