Human FBPase 1 protein (Recombinant) (His-Tag) (STJP016550)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FBPase 1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FBP1 |
| Gene ID | 2203 |
| Uniprot ID | F16P1_HUMAN |
| Accession Number | NP_000498.2 |
| Immunogen | Human |
| Immunogen Region | 1-338aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in pancreatic islets. |
| Function | Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity.increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. |
| Protein Name | Fructose-1 -6-Bisphosphatase 1Fbpase 1D-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1Liver Fbpase |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | |
| Alternative Protein Names | Fructose-1 -6-Bisphosphatase 1 proteinFbpase 1 proteinD-Fructose-1 -6-Bisphosphate 1-Phosphohydrolase 1 proteinLiver Fbpase proteinFBP1 proteinFBP protein |
Information sourced from Uniprot.org