Human FBN2 protein (Recombinant) (N-GST) (STJP004619)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FBN2-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | FBN2 |
| Gene ID | 2201 |
| Uniprot ID | FBN2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr1550-Cys1791 |
Additional Info
| Post Translational Modifications | Placensin: N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Placensin: Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels. |
| Protein Name | Fibrillin-2 Cleaved Into - Placensin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedFibrillin-2 And Placensin Chains Are Still Linked Together During The Secretion From CellsBut Are Subsequently Separated By FurinFibrillin-2: SecretedExtracellular SpaceExtracellular MatrixPlacensin: SecretedSecreted By Placental Cells |
| Alternative Protein Names | Fibrillin-2 Cleaved Into - Placensin proteinFBN2 protein |
Information sourced from Uniprot.org