Human FAS/CD95 (Tumor Necrosis Factor Receptor Superfamily Member 6) Antibody Pair (STJAP00195)
SPECIFICATIONS
ClonalityPolyclonal/Polyclonal
HostRabbit/Rabbit
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human FAS/CD95 protein.Detection Immunogen: Recombinant Human FAS/CD95 protein.
General Information
| Short Description | This FAS/CD95 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A & Antigen Affinity.Detection Purification: Protein A & Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | FAS |
| Gene ID | 355 |
| Uniprot ID | TNR6_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human FAS/CD95 protein.Detection Immunogen: Recombinant Human FAS/CD95 protein. |
Additional Info
| Post Translational Modifications | (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 6Apo-1 AntigenApoptosis-Mediating Surface Antigen FasFaslg ReceptorCd Antigen Cd95 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75157 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform 2: SecretedIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Secreted |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Receptor Superfamily Member 6 antibody pairApo-1 Antigen antibody pairApoptosis-Mediating Surface Antigen Fas antibody pairFaslg Receptor antibody pairCd Antigen Cd95 antibody pairFAS antibody pairAPT1 antibody pairFAS1 antibody pairTNFRSF6 antibody pair |
Information sourced from Uniprot.org