Human FAM49B protein (Recombinant) (His-Tag) (STJP018140)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FAM49B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYRIB |
| Gene ID | 51571 |
| Uniprot ID | CYRIB_HUMAN |
| Accession Number | NP_057707 |
| Immunogen | Human |
| Immunogen Region | 1-324aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Ubiquitinated at Lys-74 upon Salmonella bacterial infection. |
| Function | Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress. |
| Protein Name | Cyfip-Related Rac1 Interactor BL1 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | MembraneLipid-AnchorMitochondrion |
| Alternative Protein Names | Cyfip-Related Rac1 Interactor B proteinL1 proteinCYRIB proteinCYRI proteinFAM49B proteinBM-009 protein |
Information sourced from Uniprot.org