This FAM132A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.058ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
tissue homogenates, cell lysates or other biological fluids.
Additional Info
Tissue Specificity
Widely expressed, with high expression in subcutaneous and epididymal white adipose tissues and brown adipose tissue. Expressed in adipocytes (at protein level).
Post Translational Modifications
Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.
Function
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. Adipolin fC1QTNF12: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes. Adipolin gC1QTNF12: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes.
Protein Name
AdipolinAdipose-Derived Insulin-Sensitizing FactorComplement C1q Tumor Necrosis Factor-Related Protein 12 Cleaved Into - Adipolin Fc1qtnf12Adipolin Fctrp12Adipolin Full-Length Form - Adipolin Gc1qtnf12Adipolin Cleaved FormAdipolin Gctrp12
Database Links
Cellular Localisation
Adipolin Fc1qtnf12: SecretedAdipolin Gc1qtnf12: SecretedIn Serum Is The Predominant Form
