Human FAHD1 protein (Recombinant) (His-Tag) (STJP017042)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human FAHD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FAHD1 |
| Gene ID | 81889 |
| Uniprot ID | FAHD1_HUMAN |
| Accession Number | NP_112485 |
| Immunogen | Human |
| Immunogen Region | 1-224aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitous (at protein level). |
| Function | Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Exhibits only a weak hydrolase activity on methylacetopyruvate and acetylacetone, and no activity toward acetoacetyl-CoA. |
| Protein Name | Oxaloacetate Tautomerase Fahd1 - MitochondrialAcylpyruvase Fahd1Fumarylacetoacetate Hydrolase Domain-Containing Protein 1Fah Domain-Containing Protein 1Oxaloacetate DecarboxylaseOaa DecarboxylaseOdxYisk-Like Protein |
| Database Links | Reactome: R-HSA-70268 |
| Cellular Localisation | MitochondrionCytoplasmCytosol |
| Alternative Protein Names | Oxaloacetate Tautomerase Fahd1 - Mitochondrial proteinAcylpyruvase Fahd1 proteinFumarylacetoacetate Hydrolase Domain-Containing Protein 1 proteinFah Domain-Containing Protein 1 proteinOxaloacetate Decarboxylase proteinOaa Decarboxylase proteinOdx proteinYisk-Like Protein proteinFAHD1 proteinC16orf36 proteinYISKL protein |
Information sourced from Uniprot.org