Human FACE1/ZMPSTE24 protein (Recombinant) (N-His) (STJP010414)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human FACE1/ZMPSTE24-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ZMPSTE24 |
| Gene ID | 10269 |
| Uniprot ID | FACE1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp217-Lys347 |
Additional Info
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity. |
| Protein Name | Caax Prenyl Protease 1 HomologFarnesylated Proteins-Converting Enzyme 1Face-1Prenyl Protein-Specific Endoprotease 1Zinc Metalloproteinase Ste24 Homolog |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEarly Endosome MembraneLate Endosome Membrane |
| Alternative Protein Names | Caax Prenyl Protease 1 Homolog proteinFarnesylated Proteins-Converting Enzyme 1 proteinFace-1 proteinPrenyl Protein-Specific Endoprotease 1 proteinZinc Metalloproteinase Ste24 Homolog proteinZMPSTE24 proteinFACE1 proteinSTE24 protein |
Information sourced from Uniprot.org