Human F7 (Coagulation Factor Vii) Antibody Pair (STJAP00510)
SPECIFICATIONS
HostGoat/Goat
ConjugationUnconjugated/Biotin
ImmunogenCapture immunogen: Recombinant Human F7 protien.Detection Immunogen: Recombinant Human F7 protien.
General Information
| Short Description | This F7 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Goat/Goat |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Antigen Affinity.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Determination Method | Colormetric |
Target Information
| Gene Symbol | F7 |
| Gene ID | 2155 |
| Uniprot ID | FA7_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human F7 protien.Detection Immunogen: Recombinant Human F7 protien. |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-S/T-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro. |
| Function | Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium. |
| Protein Name | Coagulation Factor ViiProconvertinSerum Prothrombin Conversion AcceleratorSpcaEptacog Alfa Cleaved Into - Factor Vii Light Chain - Factor Vii Heavy Chain |
| Database Links | Reactome: R-HSA-1368108Reactome: R-HSA-140834Reactome: R-HSA-159740Reactome: R-HSA-159763Reactome: R-HSA-159782 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Coagulation Factor Vii antibody pairProconvertin antibody pairSerum Prothrombin Conversion Accelerator antibody pairSpca antibody pairEptacog Alfa Cleaved Into - Factor Vii Light Chain - Factor Vii Heavy Chain antibody pairF7 antibody pair |
Information sourced from Uniprot.org